Merle Great Dane
14 Jan 2009
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 MERLE GREAT DANE PUPPY DOG MOSAIC STYLE WALL ART 8x10 PHOTO PRINT  US $14.00
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 GREAT DANE BLUE MERLE Hanes Heavyweight 50 50 Tee Shirts 0985 US $12.85
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 New Merle Great Dane Gentle Giant German Mastiff Dog Pet Christmas Ornament US $6.99
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 GREAT DANE BLUE MERLE Photo Refrigerator Magnet 0985 US $3.65
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 GREAT DANE BLUE MERLE Heavy Rubber Backed Mousepad 0985 US $9.87
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 GREAT DANE BLUE MERLE Stationery 0985 US $5.99
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 GREAT DANE BLUE MERLE Rubber Backed Coasters 0985 US $6.57
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 GREAT DANE BLUE MERLE 100 Personalized Business Cards 0985 US $12.45
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 GREAT DANE BLUE MERLE Counted Cross Stitch detailed 0985 US $9.95
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 HANDMADE PET MERLE GREAT DANE DOG PAINTING JEWELRY GLASS TILE PENDANT NECKLACE US $16.50
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 HANDMADE PET MERLE GREAT DANE PUPPY DOG JEWELRY GLASS TILE PENDANT NECKLACE US $16.00
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 HANDMADE PET MERLE GREAT DANE DOG JEWELRY GLASS TILE PENDANT NECKLACE US $16.00
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 ORIGINAL ACRYLIC MERLE GREAT DANE DOG BIRTHDAY PARTY WALL ART PAINTING 2006 US $45.00
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 MERLE GREAT DANE Love Charm Necklace Dog Tag Jewelry Silver Glass Christmas Gift US $12.50
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Merle Great Dane Videos
Baby Max ! Blue Merle Great Dane
Chatty Puppy - Mantle Merle Great Dane puppy
Merle Great Dane Q&A
Great Dane question!!!!!?
How do u know if your blue merle dane has a double or single merle gene??
It really doesn't matter if a Merle (they are only called merle not blue merle) has a double merle gene or not unless you were going to breed, however a merle gene should not be used in a breeding program regardless.
Go ot the GDCA site for more info http://www.gdca.org
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MERLE GREAT DANE PUPPY DOG MOSAIC STYLE WALL ART 8x10 PHOTO PRINT US $14.00
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GREAT DANE BLUE MERLE Hanes Heavyweight 50 50 Tee Shirts 0985 US $12.85
|
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New Merle Great Dane Gentle Giant German Mastiff Dog Pet Christmas Ornament US $6.99
|
GREAT DANE BLUE MERLE Photo Refrigerator Magnet 0985 US $3.65
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GREAT DANE BLUE MERLE Heavy Rubber Backed Mousepad 0985 US $9.87
|
GREAT DANE BLUE MERLE Stationery 0985 US $5.99
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GREAT DANE BLUE MERLE Rubber Backed Coasters 0985 US $6.57
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GREAT DANE BLUE MERLE 100 Personalized Business Cards 0985 US $12.45
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GREAT DANE BLUE MERLE Counted Cross Stitch detailed 0985 US $9.95
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HANDMADE PET MERLE GREAT DANE DOG PAINTING JEWELRY GLASS TILE PENDANT NECKLACE US $16.50
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HANDMADE PET MERLE GREAT DANE PUPPY DOG JEWELRY GLASS TILE PENDANT NECKLACE US $16.00
|
HANDMADE PET MERLE GREAT DANE DOG JEWELRY GLASS TILE PENDANT NECKLACE US $16.00
|
|
ORIGINAL ACRYLIC MERLE GREAT DANE DOG BIRTHDAY PARTY WALL ART PAINTING 2006 US $45.00
|
MERLE GREAT DANE Love Charm Necklace Dog Tag Jewelry Silver Glass Christmas Gift US $12.50
|
Merle Great Dane Videos
Baby Max ! Blue Merle Great Dane
Chatty Puppy - Mantle Merle Great Dane puppy
Merle Great Dane Q&A
Confused about the Great Dane colors?
I loooong time ago a question "What other races carry merle merle or recessive?" Great Danes I could not carry the merle gene merle danes being dominant because harlequinXharlequin merle crosses produced:. I found this breeder's site "It is, however structurally identical to his brother Spirit and is still as tall as he is y. Annie Baer has been hearing evidence CERF test with both hearing and vision is normal. He has also had a DNA test for the Merle gene. We chose dark horse Harlwood CH (Hoss) and a bull for this ...." When trash says "it has been tested for the gene merle" what really confuses me, what is a harlequin Great Dane. Many people here told me that * NO * dog can "carry" merle, is always dominant. If so, how can two harls produce puppies Merle?
HARLEQUIN ***** http://www.gdca.org/uderstandingharlemerlespots.htm GEN FOUND! ***** Http: / / www.gdca.org / health / breakingnews.htm Dr. Leigh Anne Clark and his colleagues at Clemson University have recently discovered a gene that causes the harlequin phenotype and is awaiting publication. The discovery is most interesting, since it appears that the harlequin gene is not a "color (pigment-producing) gene at all. Simply alters the gene harlequin the effect of the merle gene, so that regions diluted (merle coloration) observed are largely removed from the pattern of the layer, leaving behind the color of the dog every second is known as a harlequin. So now there is proof positive that all the harlequins are genetically merles. The old idea of a "gene switch" remains basically correct and helps the uninitiated understand the interaction of Harl and merle alleles: the "Harl gene acts upon the dogs with the merle mutation to produce a novel phenotype "get the Gray" (ie, elimination of most of all diluted pigments called merle). Harlequins are basically a "Change key" of normal (Mm) merle, in which the Harlequin gene acts in the merle gene to produce the harlequin coat pattern, so Harlequin Great Danes, Neil O'Sullivan eloquent phrase is a "double heterozygotes (HHMM)." Merle mutation is a "dominant" mutation of a gene known as SILV pigment that produces a protein called PMEL17. Merle is a semi-dominant, ie, this gene with two alleles only produces three different phenotypes: not Merle, Merle normal (heterozygous) and the white white (which is homozygous defective commonly referred to as merlikin Danish). The merle gene produces a characteristic increase in white areas and areas of decreased pigment, with patches of pigment tones and full in the heterozygote usually with homozygotes usually mostly white. No merle inherits a copy of the gene Harl. Harl The mutation is also a "dominant" mutation in the wild "type" allele reduces pigmentation. Harl mutation acts as a modifier of merle dogs, further reducing the amount of pigment is seen in the shield. Dogs without a merle gene can lead to gene invisible Harl sight. Both Harlequin and Merle Great Dane has black pigment left behind, because every normal normal Merle and Harlequin have a copy of "wild type" of merle gene from both genes and Harl. A dog with two copies of the mutation Merle and a copy of the mutation Harl appears mostly white with some black and some patches may merle in a pattern known as "white." (Any embyo receiving two copies of the gene seems absorbed Harl.) An important take home message from this research parallels recent knowledge accumulated over many decades breeder that all Harlequin and Merle Great Danes are unique snowflakes, as no two are exactly alike. This is due to the unique nature of the merle gene: for all that all the Harlequins and Merles merle inherit the same mutation, the effect can vary from dog. The coat pattern therefore can not be controlled as to the details of the distribution of pigments (ie, the patterns necessarily vary). How exactly is this effect achieved is currently being explored by the laboratory of Dr. Clark. His previous work includes the discovery of the merle gene, and the isolation of the gene on chromosome 9 harlequin (see PDF and other links below). Charitable trust the DGAC signed the advent of this research through "Harlequin Gene Project" and the Board of Directors recently voted to increase spending on the continued exploration of Dr. Clark harlequin gene and its interaction with the merle gene and others in the Great Dane. We thank Dr. Clark for his continued our race. The interest of the above is the explanation a lay of the genes that produce phenotypes Harlequin and Merle:. For a more detailed explanation, see the links below Standard Coat Color Genetics For Breeders: http://www.chromadane.com/standardcoat.htm Coat Color Alleles in dogs: http://homepage.usask.ca/ ~ schmutz / dogcolors.html Recommended Reading: Genes affecting coat color in domestic dogs: A review: http://www.ncbi.nlm.nih.gov/pubmed/18052939 Retrotransposon insertion in SILV is responsible for Merle pattern domestic dogs: http://www.pnas.org/cgi/content/abstract/0506940103v1 whole genome linkage locus is located in Great Danes harlequin on chromosome 9 http://www.ncbi.nlm.nih.gov/pubmed/18513894 Youshen Posted by JP, Chairman, H & RCommittee, DGAC 2009 granting permission to publish. you can now test both for the merle mutation and the mutation Harl, so make sure your Harlequins are hhmm. And as you can not see "Harl" but when is merle present new evidence for the gene Harl matter, especially for blankets and other blacks Harlequin. Regards, JP Youshen President, Health Research Committee Great Dane Http://www.gd Club of America
Merle Great Dane Q&A
Confused about the Great Dane colors?
I loooong time ago a question "What other races carry merle merle or recessive?" Great Danes I could not carry the merle gene merle danes being dominant because harlequinXharlequin merle crosses produced:. I found this breeder's site "It is, however structurally identical to his brother Spirit and is still as tall as he is y. Annie Baer has been hearing evidence CERF test with both hearing and vision is normal. He has also had a DNA test for the Merle gene. We chose dark horse Harlwood CH (Hoss) and a bull for this ...." When trash says "it has been tested for the gene merle" what really confuses me, what is a harlequin Great Dane. Many people here told me that * NO * dog can "carry" merle, is always dominant. If so, how can two harls produce puppies Merle?
HARLEQUIN ***** http://www.gdca.org/uderstandingharlemerlespots.htm GEN FOUND! ***** Http: / / www.gdca.org / health / breakingnews.htm Dr. Leigh Anne Clark and his colleagues at Clemson University have recently discovered a gene that causes the harlequin phenotype and is awaiting publication. The discovery is most interesting, since it appears that the harlequin gene is not a "color (pigment-producing) gene at all. Simply alters the gene harlequin the effect of the merle gene, so that regions diluted (merle coloration) observed are largely removed from the pattern of the layer, leaving behind the color of the dog every second is known as a harlequin. So now there is proof positive that all the harlequins are genetically merles. The old idea of a "gene switch" remains basically correct and helps the uninitiated understand the interaction of Harl and merle alleles: the "Harl gene acts upon the dogs with the merle mutation to produce a novel phenotype "get the Gray" (ie, elimination of most of all diluted pigments called merle). Harlequins are basically a "Change key" of normal (Mm) merle, in which the Harlequin gene acts in the merle gene to produce the harlequin coat pattern, so Harlequin Great Danes, Neil O'Sullivan eloquent phrase is a "double heterozygotes (HHMM)." Merle mutation is a "dominant" mutation of a gene known as SILV pigment that produces a protein called PMEL17. Merle is a semi-dominant, ie, this gene with two alleles only produces three different phenotypes: not Merle, Merle normal (heterozygous) and the white white (which is homozygous defective commonly referred to as merlikin Danish). The merle gene produces a characteristic increase in white areas and areas of decreased pigment, with patches of pigment tones and full in the heterozygote usually with homozygotes usually mostly white. No merle inherits a copy of the gene Harl. Harl The mutation is also a "dominant" mutation in the wild "type" allele reduces pigmentation. Harl mutation acts as a modifier of merle dogs, further reducing the amount of pigment is seen in the shield. Dogs without a merle gene can lead to gene invisible Harl sight. Both Harlequin and Merle Great Dane has black pigment left behind, because every normal normal Merle and Harlequin have a copy of "wild type" of merle gene from both genes and Harl. A dog with two copies of the mutation Merle and a copy of the mutation Harl appears mostly white with some black and some patches may merle in a pattern known as "white." (Any embyo receiving two copies of the gene seems absorbed Harl.) An important take home message from this research parallels recent knowledge accumulated over many decades breeder that all Harlequin and Merle Great Danes are unique snowflakes, as no two are exactly alike. This is due to the unique nature of the merle gene: for all that all the Harlequins and Merles merle inherit the same mutation, the effect can vary from dog. The coat pattern therefore can not be controlled as to the details of the distribution of pigments (ie, the patterns necessarily vary). How exactly is this effect achieved is currently being explored by the laboratory of Dr. Clark. His previous work includes the discovery of the merle gene, and the isolation of the gene on chromosome 9 harlequin (see PDF and other links below). Charitable trust the DGAC signed the advent of this research through "Harlequin Gene Project" and the Board of Directors recently voted to increase spending on the continued exploration of Dr. Clark harlequin gene and its interaction with the merle gene and others in the Great Dane. We thank Dr. Clark for his continued our race. The interest of the above is the explanation a lay of the genes that produce phenotypes Harlequin and Merle:. For a more detailed explanation, see the links below Standard Coat Color Genetics For Breeders: http://www.chromadane.com/standardcoat.htm Coat Color Alleles in dogs: http://homepage.usask.ca/ ~ schmutz / dogcolors.html Recommended Reading: Genes affecting coat color in domestic dogs: A review: http://www.ncbi.nlm.nih.gov/pubmed/18052939 Retrotransposon insertion in SILV is responsible for Merle pattern domestic dogs: http://www.pnas.org/cgi/content/abstract/0506940103v1 whole genome linkage locus is located in Great Danes harlequin on chromosome 9 http://www.ncbi.nlm.nih.gov/pubmed/18513894 Youshen Posted by JP, Chairman, H & RCommittee, DGAC 2009 granting permission to publish. you can now test both for the merle mutation and the mutation Harl, so make sure your Harlequins are hhmm. And as you can not see "Harl" but when is merle present new evidence for the gene Harl matter, especially for blankets and other blacks Harlequin. Regards, JP Youshen President, Health Research Committee Great Dane Http://www.gd Club of America
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|
MERLE GREAT DANE PUPPY DOG MOSAIC STYLE WALL ART 8x10 PHOTO PRINT US $14.00
|
GREAT DANE BLUE MERLE Hanes Heavyweight 50 50 Tee Shirts 0985 US $12.85
|
|
New Merle Great Dane Gentle Giant German Mastiff Dog Pet Christmas Ornament US $6.99
|
GREAT DANE BLUE MERLE Photo Refrigerator Magnet 0985 US $3.65
|
|
GREAT DANE BLUE MERLE Heavy Rubber Backed Mousepad 0985 US $9.87
|
GREAT DANE BLUE MERLE Stationery 0985 US $5.99
|
|
GREAT DANE BLUE MERLE Rubber Backed Coasters 0985 US $6.57
|
GREAT DANE BLUE MERLE 100 Personalized Business Cards 0985 US $12.45
|
|
GREAT DANE BLUE MERLE Counted Cross Stitch detailed 0985 US $9.95
|
HANDMADE PET MERLE GREAT DANE DOG PAINTING JEWELRY GLASS TILE PENDANT NECKLACE US $16.50
|
|
HANDMADE PET MERLE GREAT DANE PUPPY DOG JEWELRY GLASS TILE PENDANT NECKLACE US $16.00
|
HANDMADE PET MERLE GREAT DANE DOG JEWELRY GLASS TILE PENDANT NECKLACE US $16.00
|
|
ORIGINAL ACRYLIC MERLE GREAT DANE DOG BIRTHDAY PARTY WALL ART PAINTING 2006 US $45.00
|
MERLE GREAT DANE Love Charm Necklace Dog Tag Jewelry Silver Glass Christmas Gift US $12.50
|
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